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What is PLUVICTO and how does it work?

PLUVICTO is not chemotherapy.

It is the FIRST and ONLY radioligand therapy (RLT) for PSMA+ mCRPC.

  • RLT is a different type of radiation therapy that targets a biomarker called PSMA, which is present on many prostate cancer cells and also some healthy cells 

  • This means it is designed to find and attack PSMA+ cells, including cancer cells*

*May also damage healthy PSMA+ and other nearby cells.

 

Think of it in 3 steps

ATTACH: PLUVICTO attaches to PSMA proteins on the outside of a cell.

PLUVICTO mechanism of action 1

ABSORB: Then PLUVICTO is absorbed into the cell.

PLUVICTO mechanism of action 2

ATTACK: From inside the cell, PLUVICTO attacks. It releases radiation into its target, the PSMA+ cell, damaging or destroying with limited damage to surrounding cells.

PLUVICTO mechanism of action 3
mCRPC, metastatic castration-resistant prostate cancer; PSMA, prostate-specific membrane antigen; PSMA+, PSMA positive.