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In PSMA-positive mAPMN/S prostate cancer, also known as mHSPC, PLUVICTO reduced the risk of cancer worsening by an additional 28% vs hormone therapy alone. 86% of men on PLUVICTO had their tumors shrink or disappear (vs 81%). In PSMA-positive mAPMR prostate cancer, also known as mCRPC, PLUVICTO had 2 times more time without cancer worsening vs a second hormone therapy, with a median of 9.3 months vs 5.6 months. 49% of men on PLUVICTO had their tumors shrink or disappear (vs 14%).

FDA, US Food and Drug Administration; mAPMN/S prostate cancer, metastatic androgen pathway modulation-naïve or -sensitive prostate cancer; mAPMR prostate cancer, metastatic androgen pathway modulation-resistant prostate cancer; mCRPC, metastatic castration-resistant prostate cancer; mHSPC, metastatic hormone-sensitive prostate cancer; PSMA+, prostate-specific membrane antigen–positive.

PLUVICTO is not chemotherapy. It's different.1

There are different types of metastatic prostate cancer (mPC).7 Learning about your type can help determine if PLUVICTO could be right for you.

What makes PLUVICTO different? It is a targeted treatment.1

Whether you are living with mPC or caring for someone who is, watch this relatable story*

*Patient and care partner experiences are individual and vary. Rick and Melanie were compensated for their participation in this video.

Every day without cancer progression is a victory

In PSMA-positive mAPMN/S prostate cancer, also known as mHSPC: In a primary analysis, PLUVICTO reduced the risk of cancer worsening by an additional 28% vs hormone therapy alone. In an updated analysis 14 months later, PLUVICTO reduced the risk of cancer worsening by an additional 33% vs hormone therapy alone. 86% of men on PLUVICTO had their tumors shrink or disappear (vs 81%). 

In PSMA-positive mAPMR prostate cancer, also known as mCRPC: PLUVICTO had 2 times more time without cancer worsening vs a second hormone therapy. With a median of 9.3 months with PLUVICTO vs 5.6 months with a second hormone therapy. In an updated analysis 17 months later, it was a median of 11.6 months with PLUVICTO vs 5.6 months. 49% of men on PLUVICTO had their tumors shrink or disappear (vs 14%).

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References: 1. Pluvicto. Prescribing information. Novartis Pharmaceuticals Corp. 2. Armstrong AJ, Morris MJ, Abida W, et al. Trial design and objectives for patients with prostate cancer: recommendations from the Prostate Cancer Working Group. J Clin Oncol. 2026;44(13):1249-1265. doi:10.1200/JCO-25-02834 3. Data on file. PLUVICTO PSMAddition trial. Novartis Pharmaceuticals Corp; September 2025. 4. Data on file. PLUVICTO PSMAddition final data. Novartis Pharmaceuticals Corp; May 2026. 5. NCI Dictionary of Cancer Terms. ORR. Accessed May 15, 2026. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/orr 6. Morris MJ, Castellano D, Herrmann K, et al. 177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate cancer (PSMAfore): a phase 3, randomised, controlled trial. Lancet. 2024;404(10459):1227-1239. doi:10.1016/S0140-6736(24)01653-2 7. Bernal A, Bechler AJ, Mohan K, et al. The current therapeutic landscape for metastatic prostate cancer. Pharmaceuticals (Basel). 2024;17(3):351. doi:10.3390/ph17030351