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About PSMA+ Metastatic Prostate Cancer
If you have metastatic prostate cancer (mPC), it means the cancer has spread beyond your prostate to other parts of the body, like bones or lymph nodes.1 This usually means that surgery is not an option and that you will be treated with medications that go throughout your body.2
There are different types of mPC:
Are you newly diagnosed with mPC or did you have prostate cancer that came back as metastatic while still responding to hormone therapy? Then you have metastatic androgen pathway modulation-naïve or -sensitive prostate cancer (mAPMN/S PC), also known as metastatic hormone-sensitive prostate cancer (mHSPC)2-4
Has your mPC stopped responding to hormone therapy that lowers testosterone? Then you have metastatic androgen pathway modulation-resistant prostate cancer (mAPMR PC), also known as metastatic castration-resistant prostate cancer (mCRPC)2,5
In addition, more than 80% of men with prostate cancer have PSMA-positive (PSMA+) status, and you could too.6-8
For full definitions of terms used on this page, visit the Glossary.
PSMA, prostate-specific membrane antigen.
What is metastatic hormone-sensitive prostate cancer (mHSPC)?
mHSPC is prostate cancer that has spread to other parts of the body and still responds to hormone therapy. "Hormone-sensitive" means that the cancer responds to hormone therapy that lowers testosterone, like androgen deprivation therapy.2
Prostate cancer relies on testosterone to grow. Hormone therapy is usually given to stop testosterone from helping the growth and spread of prostate cancer.9
An mHSPC diagnosis can naturally bring up many feelings: shock, distress, being overwhelmed. Educating yourself about mHSPC and how it is treated can help you better navigate making decisions.
mHSPC can progress and stop responding to hormone therapy
When mHSPC no longer responds to hormone therapy that lowers testosterone, it can progress to another type of cancer that is medically known as metastatic castration-resistant prostate cancer (mCRPC).2
About half of men with mHSPC stop responding to hormone therapy* and are diagnosed with mCRPC within 2 years.10
What is metastatic castration-resistant prostate cancer (mCRPC)?
If prostate cancer is "castration resistant," it is no longer responding to surgical or hormone treatment that lowers testosterone.2
Hearing that metastatic prostate cancer has stopped responding to testosterone-lowering hormone therapy can be a lot for you and your loved ones to process. When you get news like this, you may find it helpful to learn about your options and take an active role in your treatment decisions. After all, you are the expert on yourself.
Many other men like you have mCRPC
You may recognize yourself in one of these descriptions of men living with mCRPC:
See PLUVICTO results for men like this
Your PSMA status can help determine your treatment options12
PSMA, or prostate-specific membrane antigen, is normally found on prostate cells, and its levels are up to 1000 times higher in prostate cancer cells.13
PSMA is different than PSA14
PSA, or prostate-specific antigen, is a protein made by the prostate that is numerically measured through a blood test. High levels of PSA can tell you and your doctor that cancer may be present somewhere in the body.14
A key next step is a PSMA-PET scan—ask your doctor about getting it to determine whether PLUVICTO could be right for you.16
Want to see how other people are navigating conversations about PSMA with their doctors?*
Watch a discussion between a doctor and care partner about the role PSMA plays in understanding treatment options.
*Patient and health care provider experiences are individual and vary. Donald and Dr Koontz were compensated for their participation in this video.
What should you know about the prostate?
The prostate is a gland found only in the male reproductive system; therefore women cannot get prostate cancer. The prostate gland is located just below the bladder and in front of the rectum. It produces fluid that makes up a part of semen.17
If you or a loved one has been diagnosed with metastatic prostate cancer, this might be the first time that you’re really thinking about what the prostate does in the body.
Cancer that starts in the prostate can spread18
Want to get informed while navigating treatment decisions with your doctor?
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